UCD has developed a series of bacterial antigens which have proven effective in proof-of-concept studies and which the aim is to further develop and translate to humans. The lead target antigen is 22 kDa cytosolic bacterial protein and is currently His-tagged to facilitate affinity purification. UCD have developed a lab-scale expression and purification protocol, which will be provided to the successful contractor. We require contract protein manufacture and purification services. The purpose of the work is to appropriately scale-up the antigen to produce ~200mg batches of protein at a standard that will confirm feasibility of technology transfer and that can be used in GLP toxicology studies in mice, to ensure safety of the developed product. Ultimately, UCD would like the process to be amenable to production in a GMP facility in the future.
Deadline
The time limit for receipt of tenders was 2025-10-16.
The procurement was published on 2025-09-26.
Contract notice (2025-09-26) Object Scope of the procurement
Title: Contract for the Provision for the Manufacture of Vaccine Antigen
Reference number: UCDOPP5538
Short description:
โUCD has developed a series of bacterial antigens which have proven effective in proof-of-concept studies and which the aim is to further develop and...โ
Short description
UCD has developed a series of bacterial antigens which have proven effective in proof-of-concept studies and which the aim is to further develop and translate to humans. The lead target antigen is 22 kDa cytosolic bacterial protein and is currently His-tagged to facilitate affinity purification. UCD have developed a lab-scale expression and purification protocol, which will be provided to the successful contractor. We require contract protein manufacture and purification services. The purpose of the work is to appropriately scale-up the antigen to produce ~200mg batches of protein at a standard that will confirm feasibility of technology transfer and that can be used in GLP toxicology studies in mice, to ensure safety of the developed product. Ultimately, UCD would like the process to be amenable to production in a GMP facility in the future.
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Type of contract: supplies
Products/services: Vaccines๐ฆ
Estimated value excluding VAT: 100 000 EUR ๐ฐ
Description
Description of the procurement:
โUCD has developed a series of bacterial antigens which have proven effective in proof-of-concept studies and which the aim is to further develop and...โ
Description of the procurement
UCD has developed a series of bacterial antigens which have proven effective in proof-of-concept studies and which the aim is to further develop and translate to humans. The lead target antigen is 22 kDa cytosolic bacterial protein and is currently His-tagged to facilitate affinity purification. UCD have developed a lab-scale expression and purification protocol, which will be provided to the successful contractor. We require contract protein manufacture and purification services. The purpose of the work is to appropriately scale-up the antigen to produce ~200mg batches of protein at a standard that will confirm feasibility of technology transfer and that can be used in GLP toxicology studies in mice, to ensure safety of the developed product. Ultimately, UCD would like the process to be amenable to production in a GMP facility in the future.
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Additional products/services: Pharmaceutical products๐ฆ
Place of performance: Dublin๐๏ธ
Duration: 4 (MONTH)
The time frame below is expressed in number of months.
Title
Lot Identification Number: LOT-0001
Procedure Type of procedure
Open procedure โ Administrative information
Time limit for receipt of tenders or requests to participate: 2025-10-16 00:00:00 ๐
Conditions for opening of tenders: 2025-10-16 00:30:00 ๐
Conditions for opening of tenders (place): https://www.etenders.gov.ie/epps/cft/prepareViewCfTWS.do?resourceId=6637271
Languages in which tenders or requests to participate may be submitted: English ๐ฃ๏ธ
Minimum time frame during which the tenderer must maintain the tender: 6
Complementary information Review body
Name: The High Court of Ireland
National registration number: The High Court of Ireland
Postal address: Four Courts, Inns Quay, Dublin 7
Postal code: D07 WDX8
Postal town: Dublin
Region: Dublin๐๏ธ
Country: Ireland ๐ฎ๐ช
E-mail: highcourtcentraloffice@courts.ie๐ง
Phone: +353 1 8886000๐ Service from which information about the review procedure may be obtained
Name: The High Court of Ireland
National registration number: The High Court of Ireland
Postal address: Four Courts, Inns Quay, Dublin 7
Postal code: D07 WDX8
Postal town: Dublin
Region: Dublin๐๏ธ
Country: Ireland ๐ฎ๐ช
E-mail: highcourtcentraloffice@courts.ie๐ง
Phone: +353 1 8886000๐ Information about electronic workflows
Electronic invoicing will be accepted
Electronic ordering will be used
Electronic payment will be used
Source: OJS 2025/S 186-634422 (2025-09-26)