UL0283 - UL0283 - Supply and deliver of a national Powder extrusion facility to the University of Limerick

Quantity or scope

General Description.As part of the Bernal Project, UL is establishing a National Pharmaceutical Processing Suite which will further enhance the capacity and capabilities of the Solid State Pharmaceutical Cluster (SSPC) in support of the Pharmaceutical Sector in Ireland. Included in this suite will be a Powder Extrusion Suite for the development of novel pharmaceutical solid dosage formulations. The suite will comprise of pharmaceutical extrusion equipment with integral Process Analytical Technology, providing the basis for an advanced academic and pharmaceutical manufacturing capability in Ireland. The state-of-the-art features, which are nationally unique, include the provision of real-time analysis provided by in-situ Raman Spectroscopy and the capability of continuous dry granulation processing.Technical Specifications.Specific requirements:An essential aspect of this proposal is that the equipment within the suite has been specifically indentified to allow detailed investigations of pharmaceutical extrusion processes in bench scale systems, which can be used to investigate process parameters of small volume, novel formulations. This processing capability along with appropriate software and storage package, to monitor and record operating parameters, is seen as essential by industry. The main feature of the system will be facilitation of Raman spectroscopic analysis for in-line monitoring, control and optimisation of the process. The incorporation of the Torque Rheometer, Coater Dryer and Mixer Granulator within the suite will mean that, for the first time, a complete powder processing suite will be available for academic and industry users in Ireland.The tender will comprise of 2 lots. Lot 1 will be a RAMAN PAT High Resolution Raman Microscope System and Lot 2 will be a Pharmaceutical Powder Extrusion Suite consisting of the following pieces of equipment - Pilot scale screen extruder, Pilot scale spheronizer, Bench scale screen extruder, Bench scale spheronizer, Bench scale coater/dryer, Bench scale Mixer/Granulator and a Mixer Torque Rheometer.450 000

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